Doctor's Best, Best Benfotiamine, 300 mg - 60 Veggie Caps

• Science-Based Nutrition
• Dietary Supplement
• BenfoPure
• Japanese Benfotiamine
• Helps Promote Nerve Health
• Vegan
• Non-GMO
• Gluten Free

Benfotiamine (S-benzoylthiamine-O-monophosphate) is a derivative of thiamin (Vitamin B1). Benfotiamine is fat-soluble and more bioavailable than thiamin. Benfotiamine raises the blood level of thiamin diphosphate (TDP), the most biologically active co-enzyme or thiamin, which is an essential cofactor for three enzymes involved in energy production.

• Helps maintain healthy glucose metabolism
• Helps control formation of Advanced Glycation Endproducts (AGEs)
• Helps support nerve integrity and function
• Support against oxidative stress

Benfotiamine displays direct antioxidant action in vitro, and preliminary research with human subjects suggests that this activity can be advantageous in helping to safeguard the integrity of human DNA by increasing the antioxidant capacity of plasma. In the laboratory, when human, rat, and porcine kidney cells were exposed to toxins that assault the integrity of DNA, benfotiamine was able to reduce oxidative stress under these circumstances. Benfotiamine, like vitamins C and E, can deter the activation of NF-B (a DNA-binding factor known to be activated by oxidative stress-generated reactive oxygen species) for more balanced immune responses. Furthermore, recent in vitro results suggest that the beneficial antioxidant properties of benfotiamine could work against some forms of lipid peroxidation. An animal model suggests that during oxidative stress generated by excess glucose, benfotiamine has the capacity to reduce levels of superoxide and hydroxyl radicals in the heart. Similarly, an animal model of induced oxidative stress in the cerebral cortex (the outer most layer of the brain) suggests a beneficial antioxidant effect of benfotiamine.

Benfotiamine increases blood and tissue levels of thiamin pyrophosphate (TPP), the biologically active co-enzyme form of thiamin.1, 7, 13 TPP acts as a co-enzyme for three critical enzymes involved in glucose metabolism: 1) transketolase, 2) pyruvate dehydrogenase, and 3) -ketoglutarate decarboxylase.14 The latter two enzymes are involved in utilizing glucose for fuel. Thus, TTP is vital to the cell’s energy supply.

Stimulates transketolase, a cellular enzyme essential for maintenance of normal glucose metabolic pathways.

 

MORE INFORMATION

Suggested Use:
Take 1 capsule daily, with or without food, or as recommended by a nutritionally-informed physician.
 
Other Ingredients:
Microcrystalline cellulose, modified cellulose (vegetarian capsule), silicon dioxide.

Warnings:
Store in a cool dry place.